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Arthrotec contains a combination of Diclofenac Sodium and Misoprostol. Arthrotec is a nonsteroidal anti-inflammatory drug (NSAID). It is utilized in hormones reduction that causes inflammation and pain in the body. Misoprostol reduces stomach acid and replaces protective substances in the stomach that are reduced by NSAIDs. It is often used in the treatment of osteoarthritis and rheumatoid arthritis in people at high risk for developing stomach or intestinal ulcers.

Arthrotec (generic)


Item Name Quantity Consultation Request This Medication
(Generic Arthrotec)
Diclofenac Sodium / Misoprostol 50mg/200mcg
60 Tablets INCLUDED Click Here
(Generic Arthrotec)
Diclofenac Sodium / Misoprostol 50mg/200mcg
90 Tablets INCLUDED Click Here
(Generic Arthrotec)
Diclofenac Sodium / Misoprostol 75mg/200mcg
60 Tablets INCLUDED Click Here
(Generic Arthrotec)
Diclofenac Sodium / Misoprostol 75mg/200mcg
90 Tablets INCLUDED Click Here

Arthrotec (brand)


Item Name Quantity Consultation Request This Medication
Arthrotec (brand)
Diclofenac Sodium / Misoprostol 50mg/200mcg
60 Tablets INCLUDED Click Here
Arthrotec (brand)
Diclofenac Sodium / Misoprostol 50mg/200mcg
90 Tablets INCLUDED Click Here
Arthrotec (brand)
Diclofenac Sodium / Misoprostol 75mg/200mcg
60 Tablets INCLUDED Click Here
Arthrotec (brand)
Diclofenac Sodium / Misoprostol 75mg/200mcg
90 Tablets INCLUDED Click Here




PATIENTS MUST BE ADVISED OF THIS ABORTIFACIENT PROPERTY. ARTHROTEC should not be used in women of childbearing potential unless the patient requires nonsteroidal anti-inflammatory drug (NSAID) therapy and is at high risk of developing gastric or duodenal ulceration or for developing complications from gastric or duodenal ulcers associated with the use of the NSAID (see WARNINGS). In such patients, ARTHROTEC may be prescribed if the patient:

- registered a negative serum pregnancy test within 2 weeks prior to beginning therapy.
- is willing to comply with effective contraceptive measures.
- has received both oral and written warnings of the hazards of misoprostol, the risk of possible contraception failure, and the danger to other women of childbearing potential should the drug be taken by mistake.
- will begin ARTHROTEC only on the second or third day of the next normal menstrual period.

Cardiovascular Risk: THE CONSUMPTION OF NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients who are experiencing cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS).

ARTHROTEC is contraindicated for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk: NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).



USES: Arthrotec primarily utilized to relieve pain, swelling (inflammation), and joint stiffness caused by arthritis. Reducing these symptoms helps you do more of your normal daily activities. Diclofenac is known as a nonsteroidal anti-inflammatory drug (NSAID). Misoprostol protects the stomach from diclofenac's irritating effects. This combination medication is used to treat arthritis in people at high risk of developing stomach ulcers and complications of a serious nature such as bleeding.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

HOW TO USE: Read the Patient Information Leaflet and the Medication Guide provided by your pharmacist before you start using Arthrotec and each time you get a refill. If you have any questions regarding the information, consult your doctor.

Take Arthrotec by mouth with 8 oz. of water (or 240 milliliters) unless your doctor directs you otherwise. Avoid laying down for at least 10 minutes after taking Arthrotec.

Swallow Arthrotec whole and do not crush or dissolve the tablets. Doing so may increase side effects.

Take Arthrotec with food to prevent stomach upset and to reduce the chances of diarrhea. Avoid taking antacids that contain magnesium while using Arthrotec because they may worsen diarrhea. If you need an antacid, consult your doctor or pharmacist to help you choose a product.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To minimize side effect risks (e.g., stomach bleeding), use Arthrotec at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For ongoing conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

Take Arthrotec regularly in order to get the most benefit from it. Remember to take it at the same times each day. It may take up to 2 weeks of regular use before the full benefits of this medication take effect.

Contact your doctor if your condition worsens.

SIDE EFFECTS: Reference the Warning section.

Diarrhea and upset stomach may occur within a few weeks after you start taking Arthrotec, and usually last for about 1 week. See How to Use for ways to reduce diarrhea.

Nausea, heartburn, gas, stomach pain, constipation, headache, drowsiness, and dizziness may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Rarely, diarrhea can become so severe and persistent that it may lead to a large loss of your body's water and minerals (dehydration). Be sure to drink plenty of fluids and get enough minerals/electrolytes to prevent dehydration. Tell your doctor immediately if you develop any of the following signs: severe/persistent diarrhea, stomach cramps, severe dizziness, decreased amount of urine, muscle weakness.

Tell your doctor immediately if any of these unlikely but serious side effects occur: difficult/painful swallowing, swelling of the hands/feet, sudden/unexplained weight gain, vision changes, hearing changes (e.g., ringing in the ears), mental/mood changes (e.g., depression), fast/pounding heartbeat, persistent/severe headache, fainting, unusual/heavy vaginal bleeding, menstrual problems/irregular periods, unusual tiredness.

Tell your doctor immediately if any of these rare but very serious side effects occur: change in the amount of urine, easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), unexplained stiff neck, seizures.

Arthrotec may rarely cause serious (possibly fatal) liver disease. If you notice any of the following rare but very serious side effects, stop taking diclofenac/misoprostol and tell your doctor immediately: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.

A very serious allergic reaction to Arthrotec is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not necessarily a comprehensive list of possible side effects. If you notice other effects not listed above, contact your doctor immediately.

PRECAUTIONS: Before taking Arthrotec, tell your doctor if you are allergic to either of these drugs; or to aspirin or other NSAIDs (e.g., ibuprofen, naproxen, celecoxib); or if you have any other allergies. Arthrotec may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your doctor for more details.

Arthrotec should not be used if you have certain medical conditions. Before using Arthrotec, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), recent heart bypass surgery (CABG), certain liver problem (hepatic porphyria).

Before using Arthrotec, tell your doctor or pharmacist your medical history, especially of: liver disease, diabetes that is not properly controlled, stomach/intestine/esophagus problems (e.g., bleeding, ulcers, inflammatory bowel disease), heart disease (e.g., history of heart attack), high blood pressure, stroke, swelling (edema, fluid retention), blood disorders (e.g., anemia), bleeding or clotting problems, asthma, growths in the nose (nasal polyps).

Kidney problems can sometimes occur with the use of NSAID medications, including diclofenac. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine.

Before having surgery, tell your doctor or dentist that you are using Arthrotec.

Arthrotec may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Diclofenac may cause stomach bleeding. Daily use of alcohol and tobacco may increase your risk for stomach bleeding, especially when combined with Arthrotec. Limit alcohol and stop smoking. Contact your doctor for more information.

Arthrotec may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Arthrotec must be avoided during pregnancy. It can harm the unborn baby and mother. Use reliable forms of birth control to prevent pregnancy while taking Arthrotec. If you become pregnant or think you may be pregnant, inform your doctor immediately. See Warning section.

Arthrotec passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

WARNING: Arthrotec is a combination of 2 drugs, diclofenac and misoprostol. Do not take Arthrotec if you are pregnant or think that you may be pregnant. Misoprostol may cause loss of pregnancy, premature birth, or birth defects. In rare cases, serious complications (e.g., uterine rupture) have occurred when misoprostol was used to start labor or used in combination with another drug to end pregnancy after the eighth week. These complications have resulted in harm to the unborn baby and mother.

Avoid pregnancy while taking Arthrotec and for at least one month or one complete menstrual cycle after you have stopped treatment. If you become pregnant while taking Arthrotec, contact your doctor immediately.

If you are of a woman of childbearing age, do not use Arthrotec unless you require a nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac and you are at high risk of having an ulcer or ulcer complications from NSAID treatment.

Female patients be aware of the following requirements in order to use Arthrotec: 1) test negative for pregnancy within 2 weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking Arthrotec only on the second or third day of the next menstrual period.

Diclofenac may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines. This side effect can occur without warning at any time during treatment with diclofenac. The elderly are at increased risk for serious stomach/intestinal bleeding.

Drugs related to diclofenac have rarely caused blood clots to form, resulting in serious (possibly fatal) heart attacks and strokes. Arthrotec might also rarely cause similar problems. The risk of these serious side effects may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes), or with longer use of Arthrotec. Arthrotec should not be taken right before or after heart bypass surgery (CABG).

Stop taking Arthrotec and seek immediate medical attention if you notice any of the following rare but very serious side effects: black stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest pain, shortness of breath, weakness on one side of the body, sudden vision changes, slurred speech.

DRUG INTERACTIONS: See also the How to Use section. Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. Arthrotec should not be used with the following medication because very serious interactions may occur: cidofovir. If you are currently using the medication listed above, tell your doctor before starting Arthrotec. Before using Arthrotec, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: aliskiren, ACE Inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), corticosteroids (e.g., prednisone), cyclosporine, desmopressin, digoxin, lithium, methotrexate, pemetrexed, probenecid. Arthrotec may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, or ketorolac). These drugs are similar to diclofenac and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details. This website does not contain all possible interactions. Therefore, before using Arthrotec, tell your doctor of all the products you use. Keep a list of all your medications with you, and share the list with your doctor.

OVERDOSE: Symptoms of overdose may include: severe stomach pain, vomit that looks like coffee grounds, persistent diarrhea, extreme drowsiness, slow/shallow breathing, slow/irregular heartbeat, seizures.

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222.

IMPORTANT NOTES: Do not share Arthrotec with others.

Laboratory and/or medical tests (such as complete blood count, liver and kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Non-drug treatment that is approved by your doctor for arthritis (such as weight loss if needed, strengthening and conditioning exercises) may help improve your flexibility, range of motion, and joint function. Consult your doctor for specific instructions.

MISSED DOSE: If you miss a dose of Arthrotec, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store Arthrotec at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

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