AMITRIPTYLINE DRUG INFO
IMPORTANT NOTE: The
following information is intended to supplement, not substitute
for, the expertise and judgment of your physician, pharmacist or
other healthcare professional. It should not be construed to indicate
that use of the drug is safe, appropriate, or effective for you.
Consult your healthcare professional before using this drug.
TRICYCLIC ANTIDEPRESSANTS - ORAL, INJECTION
COMMON BRAND NAME(S): Adapin, Asendin,
Aventyl, Elavil, Endep, Norpramin, Pamelor, Sinequan, Surmontil,
USES: This medication is used to
treat depression, obsessive- compulsive disorders, and bed-wetting
in children over 6 years of age (enuresis).
ELAVIL: Amitriptyline is in a class of drugs called tricyclic antidepressants.
Amitriptyline has an effect on the brain by way of chemicals that cause depression.
Amitriptyline is used to relieve symptoms of depression such as feelings of sadness,
worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness;
sleeping too much; insomnia; and thoughts of death or suicide. Amitriptyline is also sometimes
used to treat certain types of pain. Elavil may also be used for purposes other than those
listed in this medication guide.
OTHER USES: Amitriptyline may
also be used to treat nerve pain, sleeping problems (insomnia),
and has other uses as determined by your doctor.
HOW TO USE: Use Elavil as prescribed.
Try to use each dose at the same time(s) each day so you remember
to routinely use it. It may take 2 to 3 weeks until this medication has a beneficial effect. Do not stop using this medication
without your doctor's approval. Nausea, headache or fatigue can
occur if the drug is suddenly stopped.
AMITRIPTYLINE INFO: While you are taking amitriptyline you may need to be
monitored for worsening symptoms of depression and/ or suicidal thoughts at
the start of therapy or when doses are changed. This concern about the
increased risk of suicidal thoughts or behaviors may be greater if you are
18 years of age or younger and are taking amitriptyline. In patients younger
than 18 years, the risk period may go beyond start of therapy or when
doses are changed. Your doctor may want you to monitor for the following
symptoms: anxiety, panic attacks, difficulty sleeping, irritability,
hostility, impulsivity, severe restlessness, and mania (mental and/ or physical
hyperactivity). These symptoms may be associated with the development of
worsening symptoms of depression and/ or suicidal thoughts or actions.
Contact your healthcare provider if you develop any new or worsening mental
health symptoms during treatment with amitriptyline. Do not stop taking
amitriptyline. It may be 4 weeks or more before you start to feel better,
but do not stop taking amitriptyline without first talking to your doctor.
Use caution when driving, operating machinery, or performing other hazardous
activities. Amitriptyline may cause drowsiness or dizziness. If you experience
drowsiness or dizziness, avoid these activities. Dizziness is likely to occur
when you rise from a sitting or lying position. Rise slowly to prevent dizziness
and a possible fall. Use alcohol cautiously. Alcohol may increase drowsiness
and dizziness while you are taking amitriptyline.
SIDE EFFECTS: May cause drowsiness,
dizziness, increased sun sensitivity or blurred vision. May initially
cause dizziness and lightheadedness when rising too quickly from
a sitting or lying position. Other side effects include heartburn,
loss of appetite, dry mouth, strange taste in mouth, anxiety, restlessness
or sweating. If any side effects persist or worsen, notify your
doctor. Report promptly: chest pain, rapid or irregular heartbeat,
difficulty urinating, nightmares, ringing in the ears, excessive
drowsiness, uncoordinated movements, fainting. Taking this medication
at bedtime may help minimize side effects. Talk to your doctor about
this. In the unlikely event you have an allergic reaction to
Amitriptyline, seek medical attention immediately. Symptoms of an allergic
reaction include: rash, itching, swelling, dizziness, trouble breathing.
If you notice other effects not listed above, contact your doctor
PRECAUTIONS: Before using this
drug tell your doctor your medical history, especially of: glaucoma,
prostate problems, decreased urine output, thyroid disease, breathing
problems, seizure problems, alcohol use, heart disease, mental/emotional
problems, liver or kidney disease, any drug allergies. Use caution
when engaging in tasks requiring alertness such as driving or operating
machinery. Consume alcohol minimally as it may result in the drowsiness
and dizziness effects of this drug. Limit exposure to hot weather
as it may lead to heat stroke. Caution is advised when using Elavil
in the elderly, because they may be more sensitive to the effects
of the drug (e.g., confusion may occur or worsen). This drug should
be used during pregnancy only if clearly needed. Discuss the risks
and benefits with your doctor. This drug may be excreted into breast
milk. The effects on the infant are not known at this time. Consult
your doctor before breast-feeding.
DRUG INTERACTIONS: Inform your
doctor about the medicines you take, especially if you take: clonidine,
guanadrel, guanethidine, MAO inhibitors (e.g., furazolidone, linezolid,
phenelzine, selegiline, tranylcypromine), cimetidine, SSRIs (e.g.,
fluoxetine, sertraline), warfarin, carbamazepine, certain diet pills
(e.g., phentermine, fenfluramine), adrenaline-type drugs (e.g.,
dopamine, ephedrine, epinephrine, pseudoephedrine, phenylephrine,
isoproterenol- some of which may be found in cough-and-cold or asthma
products), narcotic pain medications (e.g., codeine), cisapride,
St John's wort, any other prescription or nonprescription drugs
you take. Do not start or stop any medicine without doctor or pharmacist
OVERDOSE: If overdose of Amitriptyline is suspected,
contact your local poison control center or emergency room immediately.
Symptoms ofoverdose may include agitation, confusion, hallucinations,
fever, irregular movement of the eyes, seizures, change in amount
of urine, dry mouth or nose, constipation, large pupils, drowsiness,
slow or shallow breathing, dizziness, unconsciousness, unusually
fast or slow heartbeat, or flushing..
NOTES: Do not allow anyone else
to use this medication.
MISSED DOSE: If you miss a dose of Amitriptyline
and are taking more than 1 daily: do not take it if it is almost
time for the next dose, instead, skip the missed dose and resume
your usual dosing schedule. If you take it once daily at bedtime,
do not take it the following morning. Call your doctor. Do not double
the dose to catch up.
STORAGE: Store at room temperature
away from moisture and sunlight. Do not store in the bathroom. Do
not freeze liquid forms of this medication.