ADVAIR DISKUS DRUG INFO
Please note: The
following information is intended to supplement, not act as a substitute
for, the expertise and judgment of your physician, pharmacist or
other healthcare professional. It should not be misconstrued to indicate
that use of the drug is safe, appropriate, or effective for you.
Consult your healthcare professional before using this drug.
FLUTICASONE/SALMETEROL DISK INHALER - ORAL(floo-TIK-a-sone/sal-MEE-ter-ol)
COMMON BRAND NAME(S): ADVAIR DISKUS
USES: Advair Diskus is used in the control and prevention of symptoms (wheezing and shortness of breath) caused by asthma
or ongoing lung disease (such as COPD). It contains 2 primary medications: fluticasone and salmeterol. Fluticasone belongs to
a class of drugs known as corticosteroids. It works by reducing the irritation and swelling of the airways.
Salmeterol belongs to the class of drugs known as long-acting beta agonists. It works by opening airways in the lungs
to make breathing easier. Controlling symptoms of breathing problems can decrease time lost from work or school.
In order to be effective, Advair Diskus must be used on a regular schedule. Note that it does not work immediately and should not be used to relieve
sudden shortness of breath or asthma attacks. If acute breathing problems occur, use your quick-relief inhaler
(such as albuterol, also called salbutamol in some countries) as you've been prescribed.
How should this medicine be used?: Read the Medication Guide provided by your pharmacist before you start using Advair Diskus
as well as each time you get a refill. Read the patient instructions for directions on how to use this inhaler properly.
If you have any questions, ask your doctor or pharmacist.
Position Advair Diskus flat and level when using. Inhale this medication by mouth as directed by your physician,
typically twice daily (in the morning and evening, 12 hours apart). You may or may not taste/feel the
drug when you inhale. Either is normal. Do not exhale into the device.
Avoid taking the inhaler apart or washing the mouthpiece or any part of the device.
Gargle and rinse your mouth with water after each use of Advair Diskus to help prevent irritation and yeast
infections (thrush) in the mouth and throat. Do not swallow the rinse water.
Use Advair Diskus regularly in order to get the most benefit from it. Advair Diskus works best if used at evenly
spaced intervals. To help you remember, use it at the same times each day. Do not increase your dose, use Advair Diskus
more frequently, or stop using it without first consulting your doctor. Also, do not use other long-acting beta agonists
while using this medication.
If you have been using a quick-relief inhaler (such as albuterol, also called salbutamol in some countries) on a
regular daily schedule (at least 4 times daily), you must cease this schedule and only use the quick-relief inhaler
as needed for sudden shortness of breath/asthma attacks. Talk with your doctor for additional details.
If you are regularly using a different corticosteroid taken by mouth (such as prednisone), you should not stop
using it unless directed by your doctor. You may have withdrawal symptoms if the drug is suddenly stopped.
Some conditions (such as asthma, allergies) may become worse when the drug is suddenly stopped. To prevent withdrawal
symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness), your doctor may direct
you titrate down the dose of your old medication after you begin using this product.
It may take 1 week or longer before to see the full benefit of Advair Diskus. Tell your doctor if your condition persists or worsens.
Learn which of your inhalers you should use every day and which you should use if your breathing suddenly worsens.
Ask your doctor what to do if you have worsening cough or shortness of breath, wheezing, increased sputum, worsening
peak flow meter readings, increased use of your quick-relief inhaler, or if your quick-relief inhaler does not seem
to be working well. Learn when you can self-medicate and when you should get medical help right away.
What are the side effects?: Hoarseness, throat irritation, headache, or stomach upset may occur. If any of these effects persist
or worsen, tell your doctor promptly.
Remember that your doctor has prescribed Advair Diskus because he or she has judged that the benefit to you is greater
than the risk of side effects. Many people using Advair Diskus do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: white patches on tongue/in mouth,
signs of infection (such as fever, persistent sore throat), mental/mood changes (such as nervousness), difficulty sleeping,
vision problems (such as blurred vision), increased thirst/urination, muscle cramps, shaking (tremors).
Get medical help right away if any of these rare but serious side effects occur: chest pain, fast/irregular heartbeat,
severe dizziness, fainting, seizures.
A very serious allergic reaction to Advair Diskus is rare. However, get medical help right away if you notice any symptoms
of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness,
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist and let them know right away.
What precautions should I be aware of?: Before using Advair Diskus, tell your doctor or pharmacist if you are allergic to fluticasone or salmeterol;
or if you have any other allergies. This product may contain inactive ingredients (such as lactose, milk proteins), which can
cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using Advair Diskus, tell your doctor or pharmacist your medical history, especially of: current/past infections
(such as tuberculosis, herpes), high blood pressure, bone loss (osteoporosis), heart disease (such as chest pain, heart
attack, irregular heartbeat), overactive thyroid (hyperthyroidism), diabetes, eye problems (such as cataracts, glaucoma),
seizures, liver disease.
Salmeterol may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently
result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting)
that need medical attention right away.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that
may cause QT prolongation. Before using this product, tell your doctor or pharmacist of all the drugs you take and
if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation
in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase
if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea,
or vomiting. Talk to your doctor about using Advair Diskus safely.
If you have switched from a corticosteroid taken by mouth (such as prednisone tablets) to this inhaler within the past
12 months, or if you have been using this product in higher-than-usual doses for a long time, it may be more difficult
for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a
serious illness/injury, tell your doctor or dentist that you are using this medication or have used a corticosteroid
taken by mouth within the past 12 months. Tell your doctor immediately if you develop unusual/extreme tiredness or
weight loss. Carry a warning card or medical ID bracelet that says you use (or have used) corticosteroid medications.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs,
nonprescription drugs, and herbal products).
Older adults with COPD may be at greater risk for pneumonia while using this drug. Older adults may also be more
sensitive to the side effects of this drug, especially QT prolongation (see above).
Advair Diskus may slow down a child's growth if used for a long time, but poorly controlled asthma can also slow
down growth. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.
While you are pregnant, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
What are potential drug interactions?: Drug interactions may change how your medications work or increase your risk for
serious side effects. This webpage does not contain all possible drug interactions. Keep a list of all the
products you use (including prescription/nonprescription drugs and herbal products) and share it with your
doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
A product that may interact with Advair Diskus is: aldesleukin.
Other medications can affect the removal of fluticasone and salmeterol from your body, which may affect
how this product works. Examples include azole antifungals (such as ketoconazole), boceprevir, macrolide
antibiotics (such as clarithromycin), HIV protease inhibitors (such as lopinavir, ritonavir), nefazodone,
telithromycin, among others.
What if an overdose is suspected?: If overdose is suspected, contact a poison control center or emergency room immediately.
Symptoms of overdose may include: shaking (tremors), chest pain, fast/irregular heartbeat, seizures.
Additional Information: Do not share Advair Diskus with others.
Laboratory and/or medical tests (such as lung function tests, blood pressure, bone density tests) may be
performed to monitor your progress or check for side effects. Consult your doctor for more details.
Learn to use a peak flow meter, use it daily, and promptly report worsening asthma or other breathing problems
(such as readings in the yellow/red range, increased use of quick-relief inhalers).
Avoid allergens/irritants such as smoke, pollen, pet dander, dust, or molds that may worsen asthma and other
breathing problems. Because the flu virus can also worsen breathing problems, ask your doctor or pharmacist
if you should have a flu shot every year.
In adults, Advair Diskus can increase the risk of bone loss (osteoporosis) if used for a long time.
Talk with your doctor about your risk, and about available treatments for osteoporosis. Lifestyle changes
that reduce the risk of bone loss include doing weight-bearing exercise, getting enough calcium and vitamin D,
stopping smoking, and limiting alcohol. To help prevent osteoporosis later in life, encourage children to
exercise and eat a healthy diet (including calcium).
What if I miss a dose?: If you miss a dose, skip the missed dose and resume your usual dosing schedule.
Do not double the dose to catch up.
How should I store this medication?: Store at room temperature away from light, heat, and moisture. Do not store in the bathroom.
Keep all medications away from children and pets.
For the US product, do not remove the device from its original foil package until ready to use.
Discard the device 1 month after you remove it from the original foil package or after all the
doses have been used, whichever comes first.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or
local waste disposal company for more details.